Yeah usually there's a lot of people botting at Souleaters, depending on the world.
If you're gonna bot Serpent Spawns & Medusas I recommend you to use Gill set and Garlic Necklaces. Also I'd kill them with SD's! And you can add a GFB or Thunderstorm Runes shooter when 3+ monsters.
For Hellspawns -1, you can kill them with Avalanches and use SD's to kill Plaguesmiths. I recommend you def set for this.